Research bibliography
The following pages are a comprehensive bibliography of studies
divided into six categories, with citations presented in chronological
order;
1. Scientific research and related publications
The following pages are a comprehensive bibliography of studies
divided into six categories, with citations presented in chronological
order;
1. Recent Major Guidelines, Reviews and Papers; includes over
70 significant position papers
2. Studies/Abstracts; includes over 75 studies
3. Comparison Studies of Sublingual and Subcutaneous Antigen
Administration
4. Mechanisms of Sublingual Immunotherapy; current understanding
of mucosal immunity.
5. Safety and Quality-of-Life Related Studies; growing body
of evidence
6. Other Indications for Treatment; other sensitizations where
SLIT has worked
The scrutiny of SLIT has been intense, particularly in the
past five to 10 years. The volume of research and its consistency
in showing safety and efficacy is evidence of the value of
SLIT to patients. We thank you for your interest in this topic
and invite you to provide us feedback and let us know if you
would like to receive updates a new research and publications
are added.
1) Recent Major Texts, Guidelines, Reviews, Papers and Editorials
1. Marogna M et al “Long-Lasting Effects of Sublingual
Immunotherapy for House Dust Mites in Allergic Rhinitis with
Bronchial Hyperreactivity: A Long-Term (13-Year) Retrospective
Study in Real Life,” Int Arch Allergy Immunol, Vol.
142, (1) pages 70-78, October 2006.
2. Passalacqua G and G. Walter Canonica “Sublingual
immunotherapy: Update 2006,” Current Opinion Allergy
Clin Immunol, Vol. 6, pgs. 449-454, 2006.
3. Werner-Klein, Melanie “Sublingual immunotherapy
of allergic diseases,” Expert Opin.Drug Deliv Vol 3
(5) pgs. 599-612, 2006.
4. Berto, Patrizia et al “Economic evaluation of sublingual
immunotherapy vs. symptomatic treatment in adults with pollen-induced
respiratory allergy: the Sublingual Immunotherapy Pollen Allergy
Italy (SPAI) study,” Annals of Allergy, Asthma and Immunology,
Vol. 97, pgs. 615-621, November 2006.
5. Passalacqua, Giovanni, et al “New Insights in Sublingual
Immunotherapy,” Current Allergy and Asthma Reports,
Vol. 6, pgs. 407-412, 2006.
6. McEldowney, Steven J. et al “Pollen Immunotherapy:
Selection, Prevention, and Future Directions,” Current
Allergy and Asthma Reports, Vol. 4, pgs. 420-426, 2006.
7. Bousquet, Jean, Editorial “Sublingual Immunotherapy:
Validated!”, Allergy, Vol. 61, Issue S81, page 5, July
2006.
8. Burastero, Samuele E. “Sublingual immunotherapy
for allergic rhinitis: an update,” Current Opinion in
Otolaryngology & Head and Neck Surgery, Vol. 14, pgs.
197-201, 2006.
9. Didier, Alain, “Future developments in sublingual
immunotherapy,” Allergy, Vol. 61, (Suppl. 81), pages
29-31, 2006.
10. Malling, H-J, “Sublingual immunotherapy: Efficacy
– methodology and outcome of clinical trials,”
Allergy, Vol. 61, (Suppl. 81), pages 24-28, 2006.
11. Moingeon, P. “Sublingual immunotherapy: from biological
extracts to recombinant allergens,” Allergy, Vol. 61,
(Suppl. 81), pages 15-19, 2006.
12. Passalacqua, G, et al “Randomized double-blind
controlled study with sublingual carbamylated allergoid immunotherapy
in mild rhinitis due to mites,” Allergy, Vol. 61, pages
849-854, 2006.
13. Canonica, GW, Passalacqua G., “Sublingual Immunotherapy
in the Treatment of Adult Allergic Rhinitis Patients,”
Allergy, Vol. 61, page 20, July 2006.
14. Pham-Thi, N. et al “Sublingual immunotherapy in
the treatment of children,” Allergy, Vol. 61, (Suppl.
81): pages 7-10, 2006.
15. Guerra, Laura, et al “Randomized open comparison
of the safety of SLIT in a no-updosing and traditional updosing
schedule in patients with Parietaria allergy,” Allergologia
et immunopatologia, Vol. 34, No. 02, pgs. 82-83, March 2006.
16. Mascarell, L, et al “Novel Ways for Immune Intervention
in Immunotherapy: Mucosal Allergy Vaccines,” Immunol
Allergy Clin N Am, Vol. 26, pgs. 283-306, 2006.
17. Cox, Linda, et al “Sublingual immunotherapy: A
comprehensive review,” J Allergy Clin Immunology, Vol.
117, No. 5, pgs. 1021-1035, May 2006.
18. Nelson, Harold “Advances in upper airway diseases
and allergen immunotherapy,” J Allergy and Clin Immunology,
Vol. 117, No. 5, pgs. 1047-1053, May 2006.
19. Durham, Stephen et al “Sublingual immunotherapy
with once-daily grass allergen tablets: A randomized controlled
trial in seasonal allergic rhinoconjunctivitis,” Vol.
117, No. 4, pgs. 802-809, April 2006.
20. Passalacqua, Giovanni et al “Non-Injection Routes
for Allergen Immunotherapy: Focus on Sublingual Immunotherapy,”
Inflammation & Allergy – Drug Targets, Vol. 5, pgs.
43-51, 2006.
21. Passalacqua, Giovanni et al “Quantitative assessment
of the compliance with once-daily sublingual immunotherapy
regimen in real life (EASY Project: Evaluation of A novel
SLIT formulation during a Year, ” (Letter to the Editor)
J Allergy Clin Immunology, Vol. 117, Number 4, April 2006.
22. Bieber, T. Editorial “Allergen-specific sublingual
immunotherapy: less mystic, more scientific,” Allergy,
Vol. 61, pgs. 149-150, 2006.
23. Dahl R. et al, “Specific immunotherapy with SQ
standardized grass allergen tablets in asthmatics with rhinoconjunctivitis,”
Allergy, Vol. 61, pgs. 185-190, 2006.
24. Marogna, Maurizio, et al, “Clinical, functional,
and immunologic effects of sublingual immunotherapy in birch
pollinosis: A 3-year randomized controlled study,” J
Allergy Clin Immunol, Vol. 115, Number 6, pgs. 1184-1188,
June 2005.
25. Cingi, C. et al “Efficacy of long-term sublingual-oral
immunotherapy in allergic rhinitis,” ACTA Otorhinolaryngol
Ital 25, pgs. 214-219, 2005.
26. Gidaro, G.B., et al, “The safety of sublingual-swallow
immunotherapy: an analysis of published studies,” Clin
Exp Allergy, Vol. 35, pgs. 565-571, 2005.
27. Pajno, Giovanni “Allergen immunotherapy in early
childhood: between Scylla and Charybdis!,” Clin Exp
Allergy, Vol. 35, pgs. 551-553, 2005.
28. Courtney, A.U, et al, “ Childhood Asthma: Treatment
Update,” American Family Physician, Vol. 71, No. 10,
pgs. 1959-1968, May 2005.
29. Parks, Kevin “Advances in Immunotherapy: Current
Considerations and Beyond,” The Allergy and Immunology
Report, Vol. 1 No. 2, Spring 2005.
30. Bousquet, J “Sublingual immunotherapy: from proven
prevention to putative rapid relief of allergic symptoms,”
Editorial, Allergy, Vol. 60, Issue pgs. 1-3, January 2005.
31. Lambrecht, BN “Dendritic cells in the pathogenesis
of asthma” Clinical and Exp. Allergy Rev 2004, 4:123-128.
32. Nelson, Harold “Advances in upper airway diseases
and allergen immunotherapy,” Journal of Allergy and
Clinical Immunology, Vol. 113, No. 4, Pages 635-42, April
2004.
33. Passalacqua, Giovanni, et al, “Efficacy and safety
of sublingual immunotherapy,” Annals of Allergy, Asthma,
and Immunology, Vol. 93; 1, pgs. 3-12, 2004.
34. Portnoy J. “Allergen Immunotherapy in the Prevention
of Asthma” Current Opinion Allergy Clinical Immunology
4(2): 131-136, 2004.
35. Passalacqua, G, Canonica, GW, “Sublingual or injection
immunotherapy: the final answer?” Allergy 2004: 59:
37-38.
36. Malling, Hans-Jorgen “Comparison of the clinical
efficacy and safety of subcutaneous and sublingual immunotherapy:
methodological approaches and experimental results,”
Current Opinion in Allergy and Clinical Immunology, Vol. 4,
pgs. 539-542, 2004.
37. Mosages, R “The role of hyposensitization: do we
need to start rethinking?” Clinical Opinion in Allergy
and Clinical Immunology, 2004, Vol. 4, pgs. 155-157.
38. Norman, Philip S. “Immunotherapy: 1999-2004,”
Journal of Allergy and Clinical Immunology, June 2004 Vol.
113, No. 6, pgs. 1013-1023.
39. Passalacqua G, Lombardi C, Canonica GW “Sublingual
Immunotherapy: An Update,” Current Opinion in Allergy
and Clinical Immunology, Vol. 4 (1), February 2004.
40. Markert, UR and Elsner P. Local Immunotherapy in Allergy,
Chemical Immunology and Allergy (lead chapter by D. Morris,
et al,) Vol. 82, Karger, Basel, Switzerland 2003.
41. Wilson, DR Torres, LM, and Durham SR “Sublingual
immunotherapy for allergic rhinitis” (Cochrane Review),
The Cochrane Library, Oxford, England, Issue 2. 2003.
42. Canonica, G. Walter and Passalacqua, G. “Non-injection
routes for immunotherapy,” Journal of Allergy and Clinical
Immunology, Vol. 111, No. 3 pgs. 437-448, March 2003.
43. Nelson, Harold S. “Advances in upper airway diseases
and allergen immunotherapy,” Journal of Allergy and
Clinical Immunology, Vol. 111, No. 3, pgs. S793-798, March
2003.
44. Di Rienzo, V., Canonica, GW, and Passalacqua G. “Long-lasting
effect of sublingual immunotherapy in children with asthma
due to house dust mite: a 10 year prospective study,”
Clinical and Experimental Allergy, Vol. 33, pgs. 206-210,
2003.
45. Bielory L. and Heimall “Review of complementary
and alternative medicine in treatment of ocular allergies,”
Current Opinion in Allergy and Clinical Immunology, Vol. 3,
pgs. 395-399, 2003.
46. Passalacqua, G, Baena-Cagnani, Carlos, Berardi, M, Canonica,
G Walter “Oral and sublingual immunotherapy in pediatric
patients,” Current Opinion in Allergy and Clinical Immunology,
Vol. 3(2), pgs. 139-145, April 2003.
47. Li, J et al, “Allergen immunotherapy: a practice
parameter,” Journal of Allergy and Clinical Immunology,
Vol. 90, January 2003 (see Summary Statement 57, Page 27).
48. Kagi M.K. and B. Wuthrich, Review Article, “Different
methods of local allergen-specific immunotherapy,” Allergy,
Vol. 57, pgs. 379-388, 2002.
49. Reiber, Mark E. “Sublingual Administration of Allergen
Desensitization” Tennessee Medicine, pgs. 465-467, November
2002.
50. Douglass, J. and O'Hehir, R. (Editorial) "Specific
allergen immunotherapy: time for alternatives?,” Clinical
and Experimental Allergy, Vol. 32, pgs. 1-3, 2002.
51. Bousquet, J. The new ARIA guidelines: putting science
into practice, Clin Exp All Rev 2002; 2:38-43.
52. Volpe, A. Della, et al, “Sublingual Allergen-Specific
Immunotherapy in Allergic Rhinitis and Related Pathologies:
Efficacy in a Paediatric Population” International Journal
of Immunopathology and Pharmacology, Vol 15, No. 1, pgs. 35-40,
2002.
53. Malling, H. “Is Sublingual Immunotherapy Clinically
Effective?” Current Opinion Allergy and Clinical Immunology,
Vol 2, No. 6 pgs. 523-532, 2002.
54. Allergic Rhinitis and its impact on Asthma (ARIA) Workshop
Report. ARIA Workshop Group, Journal of Allergy and Clinical
Immunology, Supplement, 11/2001:Vol. 108, No. 5.
55. Bousquet, J., ARIA Workshop Group Guidelines J All Clin
Immunol pgs S242-S245, 2001.
56. Passalacqua G. & Canonica, G.W. "Allergen-Specific
Sublingual Immunotherapy for Respiratory Allergy,” BioDrugs,
Vol. 15 (8) pgs. 509-519, 2001.
57. Morris, D.L. "Current use of sublingual-swallow
immunotherapy,” Current Opinion in Otolaryngology &
Head and Neck Surgery, Vol. 9, No. 3, pgs. 179-180, June 2001.
58. Marogna, M. et al, “Clinical Practice Improvement
Program for Immunotherapy of Respiratory Allergic Diseases,”
International Journal of Immunopathology and Pharmacology,
Vol. 14, No. 2, pgs 93-101, 2001.
59. Allergen Immunotherapy: Guidelines, Update and Recommendations
of the World Health Organization, Theodoropoulos & Lockey,
Allergy & Asthma Proc. Pg. 159-66, May-June 2000, Vol.
21, No.3.
60. Frew, Anthony, et al, "Sublingual Immunotherapy,”
Journal of Allergy Clinical Immunology, pgs. 441-444, March
2001.
61. Brown, J.L. & Frew, A.J. (Editorial) "The efficacy
of oromucosal immunotherapy in respiratory allergy,”
Clinical & Experimental Allergy, Vol. 31, Is. 1, pg 8-10,
January 2001.
62. Editorial, "The efficacy of oromucosal immunotherapy
in respiratory allergy,” Clinical and Experimental Allergy,
Vol. 31, pgs. 8-10, 2001.
63. Rakoski, Jurgen and Wessner, Dirk "A Short Assessment
of Sublingual Immunotherapy,” International Archives
of Allergy and Immunology, Vol. 126, pgs. 185-187, 2001.
64. Pineda-Algorta, J. et al, “Study of the efficacy
of sublingual immunotherapy in patients with grass pollen
sensitization,” (abstract) “Mini Symposium 3 Sublingual
Immunotherapy” Allergy 55 Suppl. Vol. 63: pg. 24, 2000.
65. Ano-Garcia, M. et al, “Efficacy and safety of sublingual
immunotherapy in patients with sensitization to Dermtophagoides
pteronyssinus” (abstract) “Mini Symposium 3 Sublingual
Immunotherapy” Allergy 55 Suppl. Vol 63: pg. 24, 2000.
66. Khinchi, M.S. et al, “Clinical efficacy of sublingual-swallow
and subcutaneous immunotherapy in patients with allergic rhinoconjunctivitis
due to birch pollen. A double-blind, double dummy placebo-controlled
study (abstract), “Mini Symposium 3 Sublingual Immunotherapy”
Allergy 55 Suppl. Vol 63: pg 24, 2000.
67. Donato, R.M. Patients with allergic rhinitis from Argentine
treated with SLIT (sublingual immunotherapy) a non-injective
route - Abstract presented October 2000 IACAI Conf.
68. Malling, Hans-Jergen "Allergen-specific immunotherapy.
Present state and directions for the future,” Allergy,
Vol 54, pgs. 30-33, 1999.
69. Passalacqua, G. et al, "Oral and Sublingual Immunotherapy:
General Aspects and Critical Considerations,” WMW Themenheft:
Hyposensibilsierung, pgs 433-437, 1999.
70. Donahue, JG et al, “Utilization and cost of immunotherapy
for allergic asthma and rhinitis,” Annals of Allergy,
Asthma and Immunology, Vol. 82, pgs. 339-347, April 1999.
71. Bousquet J, Lockey R. Malling HJ, Allergen immunotherapy:
therapeutic vaccines for allergic diseases. World Health Organization
Position Paper Allergy Vol 53 Suppl 44 pgs 1-29, 1998.
72. Malling, H.J. Editorial "Sublingual Immunotherapy,”
Clinical Experimental Allergy, Vol. 26, pgs. 1228-1231, 1996.
73. Passalacqua G. et and G.W. Canonica “Alternative
routes for allergen-specific immunotherapy” J Invest
Allergol Clin Immunol, Vol. 6(2) pgs. 81-87, March-April 1996.
74. Creticos, P.S. A review of oral specific immunotherapy,
Expressions on allergen specific immunotherapy, Stallergenes
S.A., Vol. 1, June 1995. (US Based DBPC Study).
2) Studies/Abstracts
1. Dahl, Ronald, et al “Efficacy and safety of sublingual
immunotherapy with grass allergen tablets for seasonal allergic
rhinoconjunctivitis,” J Allergy Clin Immunol, Vol. 118,
No. 2, pgs. 434-440, August 2006.
2. Valovirta, E. et al, “Clinical efficacy and safety
of sublingual immunotherapy with tree pollen extract in children,”
Allergy, Vol. 61, pgs. 1177-1183, 2006.
3. Calamita, Z. et al “Efficacy of sublingual immunotherapy
in asthma: systematic review of randomized-clinical trials
using the Cochrane Collaboration method,” Allergy, Vol.
61, pgs. 1162-1172, 2006.
4. Bernardini, Roberto, et al “Sublingual immunotherapy
with a latex extract in paediatric patients: a double blind,
placebo-controlled study,” Current Medical Research
and Opinions, Vol. 22, No. 8, pgs. 1515-1522, 2006.
5. Niu, Chen-Kuang, et al, “Efficacy of sublingual
immunotherapy with high-dose mite extracts in asthma; A multi-center,
double-blind, randomized and placebo -controlled study in
Taiwan,” Respiratory Medicine, pgs 1-10.
6. Di Rienzo, V. et al, “Post-marketing survey on the
safety of sublingual immunotherapy in children below the age
of 5 years,” Clinical and Experimental Allergy, Vol.
35, Issue 5, pg. 560, May 2005.
7. Fiocchi, A. et al, “A Prospective Study on Safety
of Sublingual Immunotherapy in Children Aged 3 to 6 Years,”
Journal of Allergy and Clinical Immunology, Vol. 115, No.
2, pg S265, February 2005.
8. Tesse, R. et al, “Effects of Oral Bacterial Immunotherapy
in Children With Atopic Eczema/Dermatitis Syndrome,”
Journal of Allergy and Clinical Immunology, Vol. 115, No.
2, pg S266, February 2005.
9. Bahceciler N.N. et al, “Impact of Sublingual Immunotherapy
on Specific Antibody Levels in Children Allergic to House
Dust Mites, Int Arch Allergy Immunol, Vol. 136, No. 3, pgs.
287-294, February 2005.
10. Wilson, D.R. et al, “Sublingual immunotherapy for
allergic rhinitis: systematic review and meta-analysis*,”
Allergy, Vol. 60, Issue 1, page 4, January 2005.
11. Marogna, M et al, “Randomized controlled open study
of sublingual immunotherapy for respiratory allergy in real-life:
clinical efficacy and more,” Allergy, Vol. 59, No. 11,
pgs 1205-1210, November 2004.
12. Novembre, E. et al, “Coseasonal sublingual immunotherapy
reduces the development of asthma in children with allergic
rhinoconjunctivitis,” Journal Allergy and Clinical Immunology,
Vol. 114, No, 4, pgs 851-857, October 2004.
13. Smith, Helen et al, “Randomized controlled trial
of high-dose sublingual immunotherapy to treat allergic rhinitis,”
Journal Allergy and Clinical Immunology, Vol. 114, No. 4,
pgs. 831- 837, October 2004.
14. Savi, E, et al, “A latex-containing hepatitis-B
vaccine administered in a severely latex allergic paediatric
patient after specific sublingual immunotherapy: a case report.
Allergy, Vol. 59, No. 9, pgs. 1014-1015, September 2004.
15. Drachenberg, K.J. et al, “Sublingual specific immunotherapy
for adults and children: a post marketing surveillance study”
Allergol Immunopathol, Vol. 32, No. 2, pgs 76-81, March-April
2004.
16. Mastrandrea F. “The potential role of allergen-specific
sublingual immunotherapy in atopic dermatitis,” Am J
Clin Dermatol, Vol. 5, No. 5, pgs 281-294, 2004.
17. Cistero, B.A. et al, “Tolerance and effects on
skin reactivity to latex of sublingual rush immunotherapy
with a latex extract,” J Investig Alllergol Clin Immunol,
Vol. 14, No. 1, pgs 17-25, 2004.
18. Khinchi…Malling, “ Clinical efficacy of sublingual
and subcutaneous birch pollen allergen-specific immunotherapy:
a randomized, placebo-controlled, double-blind, double-dummy
study,” Allergy, 2004: 59: 45-53.
19. Tonnel, A.B. et al, “Allergic rhinitis due to house
dust mites: evaluation of the efficacy of specific sublingual
immunotherapy,” Allergy, Vol. 59, pgs. 491-197, 2004.
20. Bufe, A. et al, “Efficacy of sublingual swallow
immunotherapy in children with severe grass pollen allergic
symptoms: a double-blind placebo-controlled study, Allergy,
Vol. 59(5), pgs 498-504, May 2004.
21. Pajno, GB, et al, “Sublingual immunotherapy abrogates
seasonal bronchial hyperresponsiveness in children with Parietaria-induced
respiratory allergy: a randomized controlled trial dagger,”
Allergy, Vol. 59(8), pgs. 883-887, August 2004.
22. Pajno, G.B. et al, “Comparisons between injection
and sublingual immunotherapy for rhinitis and asthma in allergic
children to house dust mite or parietaria pollen. A case controlled
study,” Journal of Allergy and Clinical Immunology,
February 2004 Supplement, Vol. 113, Number 2. (abs.)
23. Niu, C. et al, “Efficacy and safety of sublingual
immunotherapy with high dose house dust mite extract in asthmatic
children – a multicenter randomized double-blind, and
placebo-controlled study, February 2004 Supplement, Vol. 113,
Number 2. (abs.)
24. Mauro, M. et al, “Efficacy and safety of subcutaneous
and sublingual immunotherapy in birch pollinosis,” Journal
of Allergy and Clinical Immunology, February 2004 Supplement,
Vol. 113, Number 2.
25. Melranci, C. Matteoli M. “Efficacy of allergoid
sublingual immunotherapy in children with asthma and/or allergic
rhinoconjunctivitis: Comparison study with drugs” Journal
of Allergy and Clinical Immunology, February 2004 Supplement,
Vol. 113, Number 2. (abs.).
26. Bassi M. et al, “High dose sublingual immunotherapy:
Economic evaluation from an Italian observational data base
study” Journal of Allergy and Clinical Immunology, February
2004 Supplement, Vol. 113, Number 2. (abs.)
27. Pajno, GB “Efficacy of sublingual immunotherapy
in asthma and eczema,” Chem Immunol Allergy, Vol. 82,
pgs 77-88, 2003.
28. Wuthrich, B et al, “Double-Blind, Placebo-Controlled
Study with Sublingual Immunotherapy in Children with Seasonal
Allergic Rhinitis to Grass Pollen,” Journal Invest Allergol
Clin Immunol, Vol. 13(3), pgs. 145-148, 2003.
29. Andre, et al, “A Double-Blind Placebo-Controlled
Evaluation of Sublingual Immunotherapy with a Standardized
Ragweed Extract in Patients with Seasonal Rhinitis,”
Int Arch Allergy Immunol, 131: pgs. 111-118, 2003.
30. Ippoliti, F, et al, “Immunomodulation during sublingual
therapy in allergic children,” Pediatric Allergy and
Immunology, Vol. 14, pgs. 216-221, 2003.
31. Pajno, G.B. et al, Abstract “Parietaria Pollen
Sublingual Immunotherapy for Asthmatic Children: Seasonal
Behavior in Methacholine PC20, Journal of Allergy and Clinical
Immunology, February 2003.
32. Mortemousque, B, et al, “House-dust mite sublingual
–swallow immunotherapy in perennial conjunctivitis:
a double-blind, placebo-controlled study,” Clinical
and Experimental Allergy, Vol. 33, pgs. 464-469, 2003.
33. Gonzalez, E. et al, Abstract “Efficacy and Safety
of a Standardized Sublingual Therapeutic Vaccine of Cat Epithelia
Extract, Journal of Allergy and Clinical Immunology, page
S200, February 2003.
34. Cirla, A.M. et al, “A pre-seasonal birch/hazel
sublingual immunotherapy can improve the outcome of grass
pollen injective treatment in bisensitized individuals. A
case-referent, two year controlled study,” Allergol
et Immunopath Vol. 31(1) 31-43, 2003.
35. Madonini, F, et al, “Long-term and preventive effects
of Sublingual Allergen Specific Immunotherapy: A retrospective,
multicentric study, Int’l Journal of Immunopathology
and Pharmacology, Vol.16 no. 1, 73-79 (2003).
36. Bordignon V. and S. Parmiani, “Variation of the
skin end-point in patients treated with sublingual specific
immunotherapy,” Journal of Investig Allergol Clin Immunol,
Vol. 13 (3): pgs. 170-176, 2003.
37. Torres Lima, M. et al, Grass pollen sublingual immunotherapy
for seasonal rhinoconjunctivitis: a randomized controlled
trial, Clin Exp Allergy 2002; 32-507-14.
38. Silvestri, M et al,. “Changes in Inflammatory and
Clinical Parameters and in Bronchial Hyperreactivity in Asthmatic
Children Sensitized to House Dust Mites Following Sublingual
Immunotherapy,” J Invest Allergol Clin Immunol (abstract)
Vol 12: No. 1 pgs 6-7, 2002.
39. Velarde-Domiquez, T. et al, Abstract “Clinical
effectiveness and security of sublingual immunotherapy as
a treatment for allergy asthma secondary to Dermaphgoides
in pediatric population,” Rev Sanid, Milit Mex Vol.
56, No. 1, pgs 10-14, 2002.
40. Molina, A. Criado et al, “Inmunoterapia con un
extracto oral de Alternaria en el asma infanil. Eficacia clinica,
seguridad, repercusiones sobre parametros in vivo e in vitro
Allergol et Immunpathol, Vol. 30(6) 319-30, 2002.
41. Olaguibel, J.M., et al, “Adherence to and Safety
of a High Dose Sublingual Immunotherapy Regimen With a Standardized
Grass Pollen Extract,” Journal Allergy Clinical Immunology,
Vol. 109, No. 1, pg. S201, January 2002.
42. Pajno, G.B. et al, “Impact of Sublingual Immunotherapy
on Seasonal Asthma of Allergic Children to Parietaria Pollen
Treated with Inhaled Fluticasone Propionate, Journal Allergy
Clinical Immunology, Vol. 109, No. 1, pg. S200, January 2002.
43. Ariano, R. et al, “Efficacy of sublingual specific
immunotherapy in Cupressaceae allergy using an extract of
Cupressus arizonica. A double blind study, Allergol Immunopathol,
Vol. 29, No. 6, pgs. 238-244, 2001.
44. Bahceciler, et al,. "Efficacy of sublingual immunotherapy
in children with asthma and rhinitis: a double-blind, placebo-controlled
study." Pediatric Pulmonology, 32:49-55 2001.
45. Caffarelli, C, et al,. "Preseasonal local allergoid
immunotherapy to grass pollen in children,” Allergy,
2000, 55, 1142-1147.
46. Course of Birch, Bat V1 and Bat V2, IgE levels following
Sublingual-Swallow and Parenteral Birch Immunotherapy. Khinchi,
Poulsen, Malling-Denmark. Dieierlaurent, Berjout, Andre-France
July 2000.
47. Valle, C. et al, "Effects of sublingual immunotherapy
in patients sensitized to Ambrosia. An open controlled study"
Allergol et Immunopathol, Vol. 28 (6) pgs 311-317, 2000.
48. Mastrandrea, F. et al, "Specific sublingual immunotherapy
in atopic dermatitis. Results of a 6-year follow-up of 35
consecutive patients,” Allergol et Immunopathol, Vol.
28 (2) pgs. 54-62, 2000.
49. Pajno, GB, et al, "Clinical and Immunological Effects
of Long-term Sublingual Immunotherapy in Asthmatic Children
Sensitized to Mites: A Double-blind Placebo Controlled Study,
Allergy, Vol. 55, pgs 842-849, 2000.
50. Guez, S. et al, "House dust mite SLIT in perennial
rhinitis: A double blind placebo controlled study, Allergy,
Vol. 55, pgs. 369-75, 2000.
51. Pradalier, A. et al, "Sublingual-swallow immunotherapy
(SLIT) with a standardized five-grass-pollen extract (drops
and sublingual tablets) versus placebo in seasonal rhinitis,”
Allergy, Vol. 54, pgs. 819-828, February 1999.
52. Bousquet, J. et al, "Sublingual-swallow immunotherapy
(SLIT) in patients with asthma due to house-dust mites: a
double blind, placebo-controlled study,” Allergy, Vol.
54 (3) pgs. 249-260, March 1999.
53. Purello, D'Ambrosio, et al, "Sublingual immunotherapy:
a double blind placebo controlled trial with Parietaria judaica
extract standardized in mass units in patients with rhinoconjunctivitis,
asthma or both,” Allergy, Vol. 54: 968-973, 1999.
54. La Rosa, Mario, et al, "Double-blind placebo-controlled
evaluation of sublingual-swallow immunotherapy with standardized
Parietaria judaica extract in children with allergic rhinoconjunctivitis,”
Journal AllergyClinical Immunology, pgs. 425-432, August 1999.
55. Passalacqua, Giovanni, et al, "Clinical and immunologic
effects of a rush sublingual immunotherapy to Parietaria species:
A double-blind, placebo-controlled trial,” J Allergy
Clin Immunol, pgs 964-968, November 1999.
56. Di Rienzo, V, et al, "Grass pollen specific sublingual/swallow
immunotherapy in children: open-controlled comparison among
different treatment protocols,” Allergol et Immunopathol,
Vol. 27 (3) pgs 145-151, 1999.
57. Vourdas, D. et al, "Double-blind, placebo-controlled
evaluation of sublingual immunotherapy with standardized olive
pollen extract in pediatric patients with allergic rhinoconjunctivitis
and mild asthma due to olive pollen sensitization,”
Allergy, Vol 53, pgs 662-672, 1998.
58. Clavel, R., Bousquet, J., et al, "Clinical efficacy
of sublingual-swallow immunotherapy: a double-blind, placebo-controlled
trial of standardized five-grass-pollen extract in rhinitis,”
Allergy, Vol. 53, pgs 493-498, May 1998.
59. Horak, F. et al, "Immunotherapy with sublingual
birch pollen extract. A short-term double blind placebo study,”
Invest Allergol Clin Immunol, V 8, No. 3, pgs. 165-71, May-Jun
98.
60. Hordijk, G.J., et al, "Sublingual immunotherapy
with a standardised grass pollen extract; a double-blind placebo-controlled
study,” Allergol, et Immunopathol., Vol. 26, No. 5,
pages 234-240.
61. Passalacqua, Giovanni, et al, "Randomised controlled
trial of local allergoid immunotherapy on allergic inflammation
in mite-induced rhinoconjunctivitis,” The Lancet, Vol.
351, pgs 629-632, February 28, 1998.
62. Luwema, R.A., et al, "Sublingual Immunotherapy with
a Standardized Grass Pollen Extract (Oralgen); a placebo controlled
study,” The Journal of Allergy and Clinical Immunology,
Vol. 99, No. 1, Part 2, Abstract #282, January 1997.
63. Passalacqua, G., et al, "Clinical and Immunological
Effects of a Long-term Sublingual-oral Immunotherapy to Mite:
A Double Blind Study,” The Journal of Allergy and Clinical
Immunology, Vol. 99, No. 1, Part 2, Abstract # 1630, January
1997.
64. Van Deusen, Matthew, et al, “Efficacy and safety
of oral immunotherapy with short ragweed” Annals of
Allergy, Asthma & Immunology, Vol. 78, pgs 573-580, June
1997.
65. Gozalo, F. et al, "Clinical efficacy and tolerance
of two year Lolium perenne sublingual immunotherapy,”
Allergol. Et Immunopathol., Vol 25 (5), pgs. 219-227, 1997.
66. Passalacqua, G. "Sublingual immunotherapy: Accumulated
experience,” J Invest Allergol Clin Immunol, Vol. 7(5),
pgs. 364-366, September/October 1997.
67. Hirsh, T. et al,. Double blind placebo controlled study
of sublingual immunotherapy with house dust mites extracts
in children. Pediatric Allergy & Immunology, 1997: 8:
21-27.
68. D'Ambrosio, F. Purello, et al, "Rush sublingual
immunotherapy in parietaria allergic patients,” Allergol.
Et Immunopathol, Vol: 21: No 4, pgs 146-151, 1996.
69. Troise, C. et al,. "Sublingual immunotherapy in
Parietaria pollen-induced rhinitis: A double-blind study,”
Journal of Investigational Allergology and Clinical Immunology,
Vol. 5(1), pgs. 25-30, 1995.
70. Clavel, R. et al,. "Reduction of Corticosteroid
Therapy by Sublingual Immunotherapy. Double Blind Study Against
Placebo of Standardised 5 Grass Pollen Extract in Rhinitis,”
Allergy, Vol. 50(26), pg. 279, 1995.
71. Giovane, A.L., et al,. "A three-year double-blind
placebo-controlled study with specific oral immunotherapy
to Dermatophagoides: evidence of safety and efficacy in paediatric
patients,” Clinical and Experimental Allergy, Vol. 24,
pgs. 53-59, 1994.
72. Sabbah, A. et al,. "A double-blind, placebo-controlled
trial by the sublingual route of immunotherapy with a standardized
grass pollen,” Allergy, Vol. 49, pgs. 309-13, 1994.
73. Casanovas, M. et. al. "Double-blind, placebo-controlled
clinical trial of preseasonal treatment with allergenic extracts
of Olea europaea pollen administered sublingually,”
Journal of Investigational Allergology and Clinical Immunology
Vol. 4(6), pgs. 305-314, November-December 1994.
74. Tari, M.G., et al,. "Immunologic evaluation of 24
month course of sublingual immunotherapy." Allergol.Et
Immunopathol., Vol. 22, No. 5, pgs. 209-216, 1994.
75. Tari, M.G., et al,. "Efficacy of sublingual immunotherapy
in patients with rhinitis and asthma due to house dust mite-A
double blind study.,” Allergol. Et Immunopathol., Vol.
18, No. 5, pgs. 277-284, 1990.
76. Leng, Xiao, et al,. "A double-blind trial of oral
immunotherapy for Artemisia pollen asthma with evaluation
of bronchial response to the pollen allergen and serum-specific
IgE antibody,” Annals of Allergy, Vol. 64, pgs. 27-31,
Jan. 1990.
77. Taudorf, Ebbe, et. al. "Oral immunotherapy in birch
pollen hay fever,” J Allergy Clinical Immunology, Vol.
80, No. 2, pgs. 153-161, Aug. 1987.
78. Van Nierkerk, C.H. and J.I De Wet. "Efficacy of
grass-maize pollen oral immunotherapy in patients with seasonal
hay-fever; a double blind study,” Clinical Allergy,
Vol. 17, pgs. 507-513, 1987.
79. Scadding, Glenis K. and J. Brostoff. "Low dose sublingual
therapy in patients with allergic rhinitis due to house dust
mite,” Clinical Allergy, Vol. 16, pgs. 483-491, 1986.
3) Comparison Studies of Sublingual and Subcutaneous Antigen
Administration
1. Khinchi…Malling, “ Clinical efficacy of sublingual
and subcutaneous birch pollen allergen-specific immunotherapy:
a randomized, placebo-controlled, double-blind, double-dummy
study,” Allergy, 2004: 59: 45-53.
2. Mungan, Dilsad, et al, "Comparison of the efficacy
of subcutaneous and sublingual immunotherapy in mite-sensitive
patients with rhinitis and asthma - a placebo controlled study,”
Annals of Allergy, Asthma, and Immunology, Vol. 82, pgs. 485-490,
May 1999.
3. Quirino, T. et al, "Sublingual versus injective immunotherapy
in grass pollen allergic patients: a double blind (double
dummy) study, Clinical and Experimental Allergy, Vol. 26,
pgs. 1253-1261, 1996.
4. Bernardis, P., et al,. "Injective versus sublingual
immunotherapy in Alternaria tenuis allergic patients,”
Journal of Investigational Allergology and Clinical Immunology,
Vol 6(1), pgs. 55-62, January-February 1996.
4) Mechanisms of Sublingual Immunotherapy
1. Rossi RE et al “Evaluation of serum IgG4 antibodies
specific to grass pollen allergen components in the follow
up of allergic patients undergoing subcutaneous and sublingual
immunotherapy,” Vaccine (2006), doi:10.1016/j.vaccine.2006.08.040.
2. Savolainen, J, et al “Sublingual immunotherapy in
children modulates allergen-induced in vitro expression of
cytokine mRNA in PBMC,” Allergy Vol. 61, pgs. 1184-1190,
2006.
3. Sun, J-B, et al “Sublingual Tolerance Induction
with Antigen Conjugated to Cholera Toxin B Subunit Induces
Foxp3+CD25+CD4+ Regulatory T Cells and Suppresses Delayed-Type
Hypersensitivity Reactions,” Scandinavian Journal of
Immunology, Vol. 64, pgs. 251-259, 2006.
4. Akdis, CA, et al “Immunological Mechanisms of Sublingual
Immunotherapy,” Allergy, Vol. 61, page 11, July 2006.
5. Ciprandi, Giorgio et al “Sublingual immunotherapy
induces spirometric improvement associated with IL-10 production:
Preliminary reports,” International Immunopharmacology,
Vol. 6, pgs. 1370-1373, 2006.
6. Jutel, M. et al “Mechanisms of allergen specific
immunotherapy – T-cell tolerance and more,” Allergy,
Vol. 61, pgs. 796-807, 2006.
7. Malling, H-J, et al “Safety and Immunological Changes
during Sublingual Immunotherapy with Standarized Quality Grass
Allergen Tablets,” J Investig Allergol Clin Immunol,
Vol. 16 (3), pages 162-168, 2006.
8. Cosmi, L. et al “Sublingual immunotherapy with Dermatophagoides
monomeric allergoid down-regulates allergen-specific immunoglobulin
E and increases both interferon-y-and interleukin-10-production,”
Clinical and Experimental Allergy, Vol. 36, pgs. 261-272,
2006.
9. Ciprandi, G. et al “Allergen-specific immunotherapy:
an update on immunological mechanisms of action,” Monaldi
Arch Chest Dis, Vol 65, No. 1, pgs 34-37 2006.
10. Ciprani, G. et Al “Sublingual immunotherapy and
regulatory T-cells,” Allergy Vol. 61, pgs. 511-513,
2006.
11. Dehlink, E et al, “Absence of systemic immunologic
changes during dose build-up phase and early maintenance period
in effective specific sublingual immunotherapy in children,”
Clinical and Experimental Allergy, Vol. 36, pgs. 32-39, 2006.
12. Moingeon, et al, “Immune mechanisms of allergen-specific
sublingual immunotherapy,” Allergy, Vol. 61, pgs. 151-165,
2006.
13. Ciprandi, G et al, “Induction of interleukin 10
by sublingual immunotherapy for house dust mites: a preliminary
report,” Annals of Allergy, Asthma & Immunology,
Vol. 95, July 2005.
14. Lambrecht, BN “Dendritic cells in the pathogenesis
of asthma” Clinical and Exp. Allergy Rev 2004, 4:123-128.
15. Jan de Heer, Hendrick, et al, “Essential Role of
Lung Plasmacytoid Dendritic Cells in Preventing Asthmatic
Reactions to Harmless Inhaled Antigen,” J Exp. Med,
Vol. 200, Number 1, pgs, 89-98, July 5, 2004.
16. Arikan, C et al,. “BCG-induced IL-12 did not improve
parameters in asthmatic children treated w/sublingual immunotherapy,”
Clinical and Exp. Allergy, 34-398-405, 2004.
17. Reich, M et al,. “Nonspecific Plasma Proteins during
Sublingual Immunotherapy,” Local Immunotherapy in Allergy,
Chem Immunol. Basel, Karger, Vol. 82, pgs. 99-108, 2003.
18. Bagnasco, et al, "Pharmacokinetics of an allergen
and a monomeric allergoid for oromucosal immunotherapy in
allergic volunteers,” Clinical and Experimental Allergy,
Vol 31, pgs. 54-60, 2001.
19. Marcucci, F. et al, "Sublingual tryptase and ECP
in children treated with grass pollen sublingual immunotherapy
(SLIT): safety and immunologic implications,” Allergy,
Vol. 56, pgs. 1091-1095, 2001.
20. Preliminary analysis of clinical parameters, plasma proteins
and T cell functions of allergic patients after up to 3 years
sublingual immunotherapy- Abstract presented October 2000
0 IACAI conference, U.R. Markert, MD.
21. Fanta, C. et al, "Systemic Immunological Changes
Induced by Administration of Grass Pollen Allergens via the
Oral Mucosa during Sublingual Immunotherapy,” Int Arch
Allergy Immunol, 120: pgs. 218-224, February 5, 1999.
22. Yuksel, H. et al, "Sublingual immunotherapy and
influence on urinary leukotrienes in seasonal pediatric allergy,”
Invest Allergol Clin Immunol, Vol. 9(5), pgs 305-313, September/October
1999.
23. Bagnasco, M et al, "Absorption and distribution
kinetics of the major Parietaria allergen administered by
noninjectable routes to healthy human beings, Journal Allergy
Clinical Immunology, Vol. 100: pgs. 13-18, 1997.
24. Giannarini, L. "Decrease of allergen-specific T
cell response induced by local nasal immunotherapy,”
Clin Exp Allergy, Vol. 28, pgs, 547-551, 1998.
5) Safety and Quality-of-Life Related Studies
1. Dunsky, E.H. et al “Anaphylaxis to sublingual immunotherapy,”
Allergy, Vol. 61, pgs 1235-1244, 2006.
2. Antico, A. et al “Anaphylaxis by latex sublingual
immunotherapy,” Allergy, Vol. 61, pgs 1236-1237, 2006.
3. Larsen, T.H., et al “Safety and tolerability of
grass pollen tablets in sublingual immunotherapy – a
phase-1 study,” Allergy, Vol. 61, pgs. 1173-1176, 2006.
4. Frati, F, et al “Dose dependence of efficacy but
not of safety in sublingual immunotherapy”, Monaldi
Arch Chest Dis, Vol. 65, No. 1, pgs. 38-40, 2006.
5. Tripodi, S, et al, “Safety and Tolerability of Ultra-Rush
Induction, Less than One Hour, of Sublingual Immunotherapy
in Children,” Int Arch Allergy Immunol, Vol. 139, pgs
149-152, 2006.
6. Kleine-Tebbe, J et al, “Safety of a SQ-standarized
grass allergen tablet for sublingual immunotherapy: a randomized,
placebo-controlled trial,” Allergy, Vol. 61, pgs. 181-184,
2006.
7. Di Rienzo, V. et al, “ Post-marketing survey on
the safety of sublingual immunotherapy in children below the
age of 5 years,” Clin Exp Allergy, Vol. 35, pgs. 560-564,
2005.
8. Scolozzi, RM “Tolerability of the allergoid sublingual
immunotherapy with a monomeric allergoid in patients with
allergic rhinitis and/or asthma” Journal of Allergy
and Clinical Immunology, February 2004 Supplement, Vol. 113,
No. 2. (abstract)
9. Silvestris, A. “Tolerability of sublingual immunotherapy
with monomeric allergoid in allergic sensitizations to house
dust mite, Parietaria and grass, Journal of Allergy and Clinical
Immunology, February 2004 Supplement, Vol. 113, No. 2. (abstract)
10. Grosclaude, M, et al, “Safety of Various Dosage
Regimens during Induction of Sublingual Immunotherapy,”
International Archives Allergy and Applied Immunology, Vol.
129 (3), pgs 248-253, March 2003.
11. Hasan, H., et al, “Short Report – Evaluation
of Immunotherapy for Seasonal and Perennial Allergic Rhinitis
Using Quality of Life Questionnaires,” Current Allergy
& Clinical Immunology, Vol. 16, No. 1, March 2003.
12. Lombardi, C. et al, "Safety of sublingual immunotherapy
with monomeric allergoid in adults: multicenter post-marketing
surveillance study,” Allergy: 56: 989-992, 2001.
13. Lombardi C, et al, "Sublingual immunotherapy is
clinically safe in patients with oral allergy syndrome,”
Allergy 2000 in press.
14. Andre, C. et al, “Safety of sublingual immunotherapy
in children and adults, “Int Arch Allergy Immunol Vol.
121, pgs. 229-234, 2000.
15. Madonini, E. et al, “Safety and Efficacy Evaluation
of Sublingual Allergen-Specific Immunotherapy – A Retrospective,
Multicenter Study, International Journal of Immunopathology
and Pharmacology, Vol. 13, No. 2, pgs. 77-81, 2000.
16. Di Rienzo, V. et al, "Post-marketing surveillance
study on the safety of sublingual immunotherapy in children,"
Allergy, Vol. 54, pgs. 1110-1113, 1999.
17. Ariano, R., et al, "Efficacy and safety of oral
immunotherapy in respiratory allergy to Parietaria judaica
pollen. A double-blind study." Invest Allergol Clin Immunol,
Vol. 8, No. 3, pgs. 155-160, May-June 1998.
18. Feliziani, V. et. al. "Safety and efficacy of sublingual
rush immunotherapy with grass allergen extracts. A double
blind study." Allergol. Et. Immunopathol., Vol. 23, No.
5, pgs. 224-230, 1995.
6) Other Indications for Treatment (Foods and Chemicals)
1. D. de Boissieu and C. Dupont “Sublingual immunotherapy
for cow’s milk protein allergy: a preliminary report,”
Allergy, Vol. 61, pgs 1238-1239, 2006.
2. Kerzl, Regina et al “Life-threatening anaphylaxis
to kiwi fruit: Protective sublingual allergen immunotherapy
effect persists even after discontinuation,” Letter
to the Editor, J Allergy Clinic Immunol, 2006.
3. Enrique, E. et al, “Sublingual immunotherapy for
hazelnut food allergy: A randomized, double-blind, placebo-controlled
study with a standardized hazelnut extract,” J Allergy
Clin Immunol, Vol. 116 (5) page 1073-1079, November 2005.
4. Bahima, A. Cistero “Tolerance and effects on skin
reactivity to latex of sublingual rush immunotherapy with
a latex extract,” J Invest Allergol Clin Immunol, Vol.
14 (1) pages 17-25, 2004.
5. Severe anaphylaxis to kiwi fruit: Immunologic changes
related to successful sublingual allergen immunotherapy, Letter
to the editor, JACI, page 1406-09, June 2003.
6. Patriarca, G. et al,. “Oral desensitizing treatment
in food allergy: clinical and immunologic results,”
Ailment Pharmacol Ther, Vol 17, pgs. 459-465, 2003.
7. Patriarca, G. “Sublingual Desensitization: A New
Approach to Latex Allergy Problem” Anesth Analg, Vol.
95, pgs. 956-960, 2002.
8. Nucera, E. “Immunological Aspects of Oral Desensitization
in Food Allergy,” Digestive Diseases and Sciences, Vol.
45, No. 3, pgs. 637-641, March 2000.
9. Patriarca, G., et al, "Food allergy in children:
results of a standardized protocol for oral desensitization,”
Hepatogastroenterology, Vol. 45 (19): pgs. 52-58, January-February
1998.
10. Morris, D.L. "Intradermal Testing and Sublingual
Desensitization for Nickel,” Cutis, Vol. 61, No. 3,
pgs. 129-132. March 1998.
11. Panzani, R.C., et al,. "Oral hyposensitization to
nickel allergy: preliminary clinical results,” Int Arch
Allergy Immunol, Vol. 107 (1-3): pgs. 251-254, May-June 1995.
|
|
